Myelin protein zero and its antibody in serum as biomarkers of n-hexane-induced peripheral neuropathy and neurotoxicity effects / 中华医学杂志(英文版)

<p><b>BACKGROUND</b>Chronic exposure to n-hexane can lead to peripheral neuropathy that no effective treatment regimen could be applied presently. This study investigated whether myelin protein zero (P0) protein and its antibody could be used to distinguish n-hexane intoxication and protect workers from peripheral neuropathy.</p><p><b>METHODS</b>We compared P0 protein and its antibody among three levels of n-hexane-exposed groups, which included 18 patients with n-hexane-induced peripheral neuropathy as case group, 120 n-hexane-exposed workers as n-hexaneexposed control group, and 147 non-hexane-exposed participants used as control group. ELISA method was applied to detect P0 protein and its antibody.</p><p><b>RESULTS</b>P0 protein in serum was significantly higher in the case group and n-hexane-exposed control group in comparison with the control group (P < 0.01). Compared with the n-hexane-exposed control group, the case group also had significant increase of P0 protein (P < 0.01). After 6 months therapy, P0 protein was observed to decrease significantly in the case group (P < 0.01). The P0 antibody in serum was significantly higher in the n-hexane-exposed control group than in the control group (P < 0.01), but not significantly different between cases and controls.</p><p><b>CONCLUSIONS</b>P0 antibodies in serum may be a short-term effect biomarker for n-hexane exposure. P0 protein in serum may be an early effective biomarker for peripheral nerve neuropathy and its biological limit value needs investigation in the future study.</p>

The distribution and drug resistance analysis of escherichia coli in clinical specimens / 中国医师进修杂志

Objective To analyze the distribution and drug resistance of Escherichia coli which separated from clinical.Methods Collecting the bacteria specimens to separating and training Escherichia coli,and then screening and monitoring drug susceptibility by The Dark Horse Microbial Analysis System,from January 2010 to July 2011.Results The Escherichia coli 486 strains which separated from clinical,the male 297 cases,female 189 cases,secretion separation 236 strains was the highest rate (48.56％),sputum 165 strains (33.95％),urine 39 strains (8.02％),and the rest of the sample 46 strains (9.47％).ESBLs 198 strains,which resistance in 19 antibiotics were higher than Escherichia coli,and it was multiple antibiotic resistance such as Aminoglycoside,Quinolone etc; Escherichia coli strains were sensitive to imipenem.Conclusion Escherichia coli which separated in surgery,respiratory tract,and urinary had a large proportion,and Resistance of Escherichia coli was serious,we should according to the Drug sensitivity of Escherichia coli,choose reasonable application of antibiotics,especially the ESBLs strains.We should strengthen the resistance testing,to provide reference for clinical rational drug use.